The King of Pop was pronounced dead after being rushed to UCLA hospital in Los Angeles in a deep coma, city and law enforcement sources told The LA Times.
Jackson, 50, suffered a cardiac arrest just after 12.00pm local time (19.00pm GMT) but paramedics were unable to revive him, a cardiologist told entertainment website TMZ.com.
Paramedics arrived at his house to find him not breathing. He was given CPR as the ambulance raced to hospital, a fire department captain told the LA Times newspaper.
Joe Jackson, the star's father, told showbiz website TMZ.com before the confirmation of his son's death: "He is not doing well."
Jackson had been about to embark on a comeback, performing 50 concerts at London's O2 Arena.
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