Days after Jennifer Aniston had a war of words with Fox News anchor Bill O'Reilly  about single motherhood, the former Friends star has created an uproar for using the word "retard."

Jennifer Aniston fires back at Bill O'Reilly over single motherhood comments

During a Thursday appearance to promote her new movie, The Switch, on Live with Regis & Kelly, Aniston also discussed dressing up like Barbra Streisand for a recent Harper's Bazaar photo shoot. "Yes, I play dress up! I do it for a living, like a retard," Aniston said.

The comments drew a quick response from many organizations that advocate for those with mental or developmental abilities, including the Special Olympics.

"Special Olympics is always disappointed when the R-word is used, especially by someone who is influential to society," a representative for the organization said in a statement to TVGuide.com. "The pervasive use of the R-word, even in an off the cuff self-deprecating manner, dehumanizes people with intellectual disabilities and perpetuates painful stereotypes that are a great source of suffering and negative stigma."