Tamblyn, who claimed her fame through the first installment of "The Sisterhood of the Traveling Pants", is playing a med student by the name of Martha M. Masters on "House M.D.".

Martha will make her debut in episode 6 which airs on October 25. While Thirteen is absent because Olivia Wilde is busy shooting for feature films, House is forced to hire a new member for his diagnostic team. Cuddy insists that House hires a woman because "she feels there's way too much testosterone on the team". Martha was eventually Cuddy's choice whom House must accept.

"Considering how horrific House is to doctors, just imagine him being your first mentor," said exec producer Katie Jacobs to TV Guide. "Her first challenge is: Can she stay on House's team?"

Martha's first task meanwhile is to treat an underhanded political campaign manager (guest star Jack Coleman), who develops hepatitis C. Coleman who was last seen on "Heroes" said, "I'm the case of the week, so I worked with almost all the doctors, including Amber, who was fantastic. I think people are going to love and relate to her role - a socially awkward kid who was always a little ahead of everyone else."

Jacobs noted that Martha is quite "uptight" when it comes to romance, adding "She comes in all wide-eyed and moralistic, and Chase loves watching House devour her. He takes her to the cleaners and it's hilarious."